|Other Names||Decapping and exoribonuclease protein, DXO, 3113-, 361-, Dom-3 homolog Z, DXO, DOM3L, DOM3Z, NG6|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6635a was selected from the N-term region of human DOM3Z. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DOM3L, DOM3Z, NG6|
|Function||Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity).|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The function of DOM3Z is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that its gene may be a housekeeping gene.
Lehner,B., Genome Res. 14 (7), 1315-1323 (2004)
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