|Other Names||Decapping and exoribonuclease protein, DXO, 3113-, 361-, Dom-3 homolog Z, DXO, DOM3L, DOM3Z, NG6|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6635a was selected from the N-term region of human DOM3Z. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DOM3L, DOM3Z, NG6|
|Function||Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity).|
|Tissue Location||Ubiquitously expressed.|
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The function of DOM3Z is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that its gene may be a housekeeping gene.
Lehner,B., Genome Res. 14 (7), 1315-1323 (2004)
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