|Other Names||Formimidoyltransferase-cyclodeaminase, Formiminotransferase-cyclodeaminase, FTCD, LCHC1, Glutamate formimidoyltransferase, Glutamate formiminotransferase, Glutamate formyltransferase, Formimidoyltetrahydrofolate cyclodeaminase, Formiminotetrahydrofolate cyclodeaminase, FTCD|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6646b was selected from the C-term region of human FTCD. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus Note=More abundantly located around the mother centriole|
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Provided below are standard protocols that you may find useful for product applications.
FTCD is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool.
Hilton,J.F., Hum. Mutat. 22 (1), 67-73 (2003)
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