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GLS2 Antibody (C-term R471) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UI32 |
|---|---|
| Clone Names | 81020124 |
| Gene ID | 27165 |
|---|---|
| Other Names | Glutaminase liver isoform, mitochondrial, GLS, L-glutaminase, L-glutamine amidohydrolase, GLS2, GA |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6650b was selected from the C-term region of human GLS2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GLS2 |
|---|---|
| Synonyms | GA |
| Function | Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. |
| Cellular Location | Mitochondrion. |
| Tissue Location | Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
GLS2 is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. This protein is functionally similar to the kidney glutaminase but is a little smaller in size. Originally thought to be liver-specific, this protein has been found in other tissues as well.
References
Szeliga,M., Glia 57 (9), 1014-1023 (2009)Maeshima,H., Prog. Neuropsychopharmacol. Biol. Psychiatry 31 (7), 1410-1418 (2007)
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