|Other Names||HIV Tat-specific factor 1, Tat-SF1, HTATSF1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6654a was selected from the N-term region of human HTATSF1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
HTATSF1 functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcription and splicing and to facilitate their reciprocal activation.
Miller,H.B., PLoS ONE 4 (5), E5710 (2009)Remoli,A.L., Biochem. J. 396 (2), 371-380 (2006)
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