PSDR1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8TC12 |
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Clone Names | 81020077 |
Gene ID | 51109 |
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Other Names | Retinol dehydrogenase 11, Androgen-regulated short-chain dehydrogenase/reductase 1, HCV core-binding protein HCBP12, Prostate short-chain dehydrogenase/reductase 1, Retinal reductase 1, RalR1, RDH11, ARSDR1, PSDR1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6666a was selected from the N-term region of human PSDR1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RDH11 |
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Synonyms | ARSDR1, PSDR1, SDR7C1 |
Function | Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12226107, PubMed:12036956, PubMed:29410696). Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal (PubMed:15865448). Has no dehydrogenase activity towards steroid (PubMed:12226107, PubMed:12036956). |
Cellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein |
Tissue Location | Predominantly expressed in the epithelial cells of prostate, in both basal and luminal secretory cell populations Expressed at low levels in spleen, thymus, testis, ovary, small intestine, colon, peripherical blood leukocytes, kidney, adrenal gland and fetal liver. Not detected in prostatic fibromuscular stromal cells, endothelial cells, or infiltrating lymphocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
RHD11, a member of the short-chain dehydrogenase/reductase (SDR) superfamily of oxidoreductases, is expressed at high levels in prostate epithelium, and its expression is regulated by androgens.
References
Persson,B., Chem. Biol. Interact. 178 (1-3), 94-98 (2009)Belyaeva,O.V., Biochemistry 42 (50), 14838-14845 (2003)
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