Myoglobin Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P02144 |
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Clone Names | 80722068 |
Gene ID | 4151 |
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Other Names | Myoglobin, MB |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6708b was selected from the C-term region of human Myoglobin. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MB (HGNC:6915) |
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Function | Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand (PubMed:30918256, PubMed:34679218). Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide (PubMed:32891753). Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity (PubMed:34679218). |
Cellular Location | Cytoplasm, sarcoplasm |
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Provided below are standard protocols that you may find useful for product applications.
Background
Myoglobin is a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of oxygen.
References
Flonta,S.E., Am. J. Pathol. 175 (1), 201-206 (2009)Kanatous,S.B., Am. J. Physiol., Cell Physiol. 296 (3), C393-C402 (2009)
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