|Other Names||Antithrombin-III, ATIII, Serpin C1, SERPINC1, AT3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6715b was selected from the C-term region of human SERPINC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Found in plasma.|
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Provided below are standard protocols that you may find useful for product applications.
SERPINC1 is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin.
Doi,T., Arch. Biochem. Biophys. 489 (1-2), 62-67 (2009)Sun,X.J., J. Biol. Chem. 264 (19), 11288-11293 (1989)
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