|Other Names||Carboxypeptidase D, Metallocarboxypeptidase D, gp180, CPD|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6725b was selected from the C-term region of human CPD. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal muscle, heart and colon carcinoma and melanoma cell lines|
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Provided below are standard protocols that you may find useful for product applications.
The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein.
Hoff,N.P., J. Clin. Immunol. 27 (6), 568-579 (2007)O'Malley,P.G., Biochem. J. 390 (PT 3), 665-673 (2005)
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