|Other Names||Gigaxonin, Kelch-like protein 16, GAN, GAN1, KLHL16|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6726c was selected from the Center region of human GAN. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton.|
|Tissue Location||Expressed in brain, heart and muscle.|
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Provided below are standard protocols that you may find useful for product applications.
GAN is a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in its gene are a cause of giant axonal neuropathy (GAN).
Nalini,A., Eur J Med Genet 51 (5), 426-435 (2008)Koop,O., Neuromuscul. Disord. 17 (8), 624-630 (2007)
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