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GAN Antibody (Center H205) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9H2C0
Clone Names 80703077
Peptide ID 80703077
Additional Information
Gene ID 8139
Other Names Gigaxonin, Kelch-like protein 16, GAN, GAN1, KLHL16
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6726c was selected from the Center region of human GAN. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GAN
Synonyms GAN1, KLHL16
Function Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton.
Tissue Location Expressed in brain, heart and muscle.
Research Areas
Citations (0)

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GAN is a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in its gene are a cause of giant axonal neuropathy (GAN).


Nalini,A., Eur J Med Genet 51 (5), 426-435 (2008)Koop,O., Neuromuscul. Disord. 17 (8), 624-630 (2007)

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$ 80.00
Cat# BP6726c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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