|Other Names||Endothelial transcription factor GATA-2, GATA-binding protein 2, GATA2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6772c was selected from the Center region of human GATA2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.|
|Tissue Location||Endothelial cells.|
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Provided below are standard protocols that you may find useful for product applications.
GATA2 is a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. This protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages.
Pan,X., et.al., J. Biochem. 127 (1), 105-112 (2000)
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