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Ku70 Antibody (Center) Blocking PeptideSynthetic peptide
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| BP6775c | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
Ku70 Antibody (Center) Blocking Peptide - Product info | |
| Primary Accession | P12956 |
| Clone Names | 81020058 |
| Calculated MW | 69843 Da |
Ku70 Antibody (Center) Blocking Peptide - Additional info | |
| Gene ID 2547 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP6775c was selected from the Center region of human Ku70. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
Ku70 Antibody (Center) Blocking Peptide - Protein Information | |
| Name XRCC6 | |
| Synonyms G22P1 | |
| Function Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose- 5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription | |
| Cellular Location Nucleus. Chromosome. | |
Ku70 Antibody (Center) Blocking Peptide - Related products
AP5089b: XRCC6 Antibody (C-term)
AP5089c: XRCC6 Antibody (Center)
AP6775a: Ku70 Antibody (N-term)
AP6775c: Ku70 Antibody (Center)
RI15763: XRCC6 predesign siRNA
LY10971a: XRCC6 Over-expression Lysate
BP5089b: XRCC6 Antibody (C-term) Blocking Peptide
BP5089c: XRCC6 Antibody (Center) Blocking peptide
BP6775a: Ku70 Antibody (N-term) Blocking Peptide
BP6775c: Ku70 Antibody (Center) Blocking Peptide
AT2136a: G22P1 Antibody (monoclonal) (M01)
Ku70 Antibody (Center) Blocking Peptide - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Ku70 is a single stranded DNA-dependent ATP-dependent helicase. It has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by p70.It is involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The Ku p70/p86 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The Ku p70/p86 dimer is probably involved in stabilizing broken DNA ends and bringing them together.
REFERENCES
Beskow,C., et.al., Br. J. Cancer 101 (5), 816-821 (2009)Tseng,R.C., et.al., Cancer 115 (13), 2939-2948 (2009)
