|Other Names||Granzyme M, 3421-, Met-1 serine protease, Hu-Met-1, Met-ase, Natural killer cell granular protease, GZMM, MET1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6792c was selected from the Center region of human GZMM. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.|
|Cellular Location||Secreted. Cytoplasmic granule. Note=Granules of large granular lymphocytes|
|Tissue Location||Highly and constitutively expressed in activated natural killer (NK) cells|
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Provided below are standard protocols that you may find useful for product applications.
GZMM cleaves peptide substrates after methionine, leucine, and norleucine.
Mahrus,S., et.al., J. Biol. Chem. 279 (52), 54275-54282 (2004)
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