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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   MTM1 Antibody (N-term) Blocking Peptide   

MTM1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q13496
Clone Names 2020806
Peptide ID 2020806
Additional Information
Gene ID 4534
Other Names Myotubularin, Phosphatidylinositol-3, 5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase, MTM1, CG2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6809a was selected from the N-term region of human MTM1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MTM1
Synonyms CG2
Function Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine- containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis.
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Late endosome. Note=Localizes as a dense cytoplasmic network. Also localizes to the plasma membrane, including plasma membrane extensions such as filopodia and ruffles. Predominantly located in the cytoplasm following interaction with MTMR12. Recruited to the late endosome following EGF stimulation.
Research Areas
Citations (0)

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MTM1 is a member of a protein family that encodes tyrosine phosphatases. Myotubularin is required for muscle cell differentiation and mutations in MTM1 have been identified as being responsible for X-linked myotubular myopathy. MTM1 is a potent phosphatidylinositol 3-phosphate phosphatase (PI(3)P). Mutations in the MTM1 gene that cause human myotubular myopathy dramatically reduce the ability of the phosphatase to dephosphorylate PI(3)P. The findings provided evidence that myotubularin exerts its effects during myogenesis by regulating the cellular levels of the inositol lipid PI(3)P.


Nandurkar, H.H., et al., Proc. Natl. Acad. Sci. U.S.A. 100(15):8660-8665 (2003).Biancalana, V., et al., Hum. Genet. 112(2):135-142 (2003).Wishart, M.J., et al., Trends Cell Biol. 12(12):579-585 (2002).Herman, G.E., et al., Hum. Mutat. 19(2):114-121 (2002).Sutton, I.J., et al., Neurology 57(5):900-902 (2001).

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$ 80.00
Cat# BP6809a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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