|Other Names||Nuclear pore complex protein Nup98-Nup96, Nuclear pore complex protein Nup98, 98 kDa nucleoporin, Nucleoporin Nup98, Nup98, Nuclear pore complex protein Nup96, 96 kDa nucleoporin, Nucleoporin Nup96, Nup96, NUP98, ADAR2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6817b was selected from the C-term region of human NUP98. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Nup98 and Nup96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC.|
|Cellular Location||Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus, nuclear pore complex. Note=NUP98 is localized to the nucleoplasmic side of the nuclear pore complex (NPC), at or near the nucleoplasmic basket (PubMed:11839768). Dissociates from the dissasembled NPC structure early during prophase of mitosis (PubMed:12802065). Colocalized with NUP153 and TPR to the nuclear basket of NPC (PubMed:11839768). Detected in diffuse and discrete intranuclear foci (PubMed:11839768). Remained localized to the nuclear membrane after poliovirus (PV) infection|
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Provided below are standard protocols that you may find useful for product applications.
Nup98 plays a role in the bidirectional transport across the nucleoporin complex (NPC). The repeat domain in Nup98 has a direct role in the transport.
Nousiainen,M., et.al., Proc. Natl. Acad. Sci. U.S.A. 103 (14), 5391-5396 (2006)
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