|Other Names||Immediate early response gene 2 protein, Protein ETR101, IER2, ETR101|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6835c was selected from the Center region of human IER2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713).|
|Cellular Location||Cytoplasm. Nucleus. Note=Cytoplasmic during quiescence, translocates to the nucleus upon stimulation|
|Tissue Location||Expressed in activated T-cells (at protein level) (PubMed:22120713). Expression increases in metastatic tumor cells (at protein level) (PubMed:22120713)|
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Provided below are standard protocols that you may find useful for product applications.
IER2 belongs to a family of immediate early response proteins, and it is thought to play a role in mediating the cellular responses to a variety of extracellular signals.
Takaya,T., et.al., Biosci. Biotechnol. Biochem. 73 (7), 1653-1660 (2009)
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