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FHL2 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q14192
Clone Names 90121120
Peptide ID 90121120
Additional Information
Gene ID 2274
Other Names Four and a half LIM domains protein 2, FHL-2, LIM domain protein DRAL, Skeletal muscle LIM-protein 3, SLIM-3, FHL2, DRAL, SLIM3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6878b was selected from the C-term region of human FHL2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FHL2
Synonyms DRAL, SLIM3
Function May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.
Cellular Location Cytoplasm. Nucleus.
Tissue Location Expressed in skeletal muscle and heart.
Research Areas
Citations (0)

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Background

LIM proteins contain a highly conserved double zinc finger motif called the LIM domain. FHL2 may function as a molecular transmitter linking various signaling pathways to transcriptional regulation. It negatively regulates the transcriptional repressor E4F1 and may function in cell growth.

References

Ding,L., et.al., J. Clin. Invest. 119 (2), 349-361 (2009)

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$ 80.00
Cat# BP6878b
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