|Other Names||Protein FAM3B, Cytokine-like protein 2-21, Pancreatic-derived factor, PANDER, FAM3B, C21orf11, C21orf76|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6891a was selected from the N-term region of human FAM3B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.|
|Cellular Location||Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure|
|Tissue Location||Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis|
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Provided below are standard protocols that you may find useful for product applications.
FAM3B has delayed effects on beta-cell function, inhibiting basal insulin secretion from a beta-cell line in a dose-dependent manner.
Yang,J., et.al., Biochemistry 44 (34), 11342-11352 (2005)
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