FAM3B Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P58499 |
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Clone Names | 90415049 |
Gene ID | 54097 |
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Other Names | Protein FAM3B, Cytokine-like protein 2-21, Pancreatic-derived factor, PANDER, FAM3B, C21orf11, C21orf76 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6891a was selected from the N-term region of human FAM3B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | FAM3B |
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Synonyms | C21orf11, C21orf76 |
Function | Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. |
Cellular Location | Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure |
Tissue Location | Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis |
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Provided below are standard protocols that you may find useful for product applications.
Background
FAM3B has delayed effects on beta-cell function, inhibiting basal insulin secretion from a beta-cell line in a dose-dependent manner.
References
Yang,J., et.al., Biochemistry 44 (34), 11342-11352 (2005)
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