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GNPAT Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O15228 |
|---|---|
| Clone Names | 90415086 |
| Gene ID | 8443 |
|---|---|
| Other Names | Dihydroxyacetone phosphate acyltransferase, DAP-AT, DHAP-AT, Acyl-CoA:dihydroxyacetonephosphateacyltransferase, Glycerone-phosphate O-acyltransferase, GNPAT, DAPAT, DHAPAT |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6909b was selected from the C-term region of human GNPAT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GNPAT (HGNC:4416) |
|---|---|
| Function | Dihydroxyacetonephosphate acyltransferase catalyzing the first step in the biosynthesis of plasmalogens, a subset of phospholipids that differ from other glycerolipids by having an alkyl chain attached through a vinyl ether linkage at the sn-1 position of the glycerol backbone, and which unique physical properties have an impact on various aspects of cell signaling and membrane biology. |
| Cellular Location | Peroxisome membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9ES71}; Matrix side {ECO:0000250|UniProtKB:Q9ES71}. Note=Exclusively localized to the lumenal side of the peroxisomal membrane {ECO:0000250|UniProtKB:Q9ES71} |
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Provided below are standard protocols that you may find useful for product applications.
Background
GNPAT is an enzyme located in the peroxisomal membrane which is essential to the synthesis of ether phospholipids.
References
Ofman,R., et.al., Biochem. Biophys. Res. Commun. 281 (3), 754-760 (2001)
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