|Other Names||Alpha-2, 8-sialyltransferase 8B, 2499-, Sialyltransferase 8B, SIAT8-B, Sialyltransferase St8Sia II, ST8SiaII, Sialyltransferase X, STX, ST8SIA2, SIAT8B, STX|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6917a was selected from the N-term region of human ST8SIA2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Highly expressed in fetal brain, kidney and heart and to a much lesser extent in adult heart and thymus|
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Provided below are standard protocols that you may find useful for product applications.
ST8SIA2 is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. This protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29.
Arai,M., et.al., Biol. Psychiatry 59 (7), 652-659 (2006)
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