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ST8SIA2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92186 |
|---|---|
| Clone Names | 90625221 |
| Gene ID | 8128 |
|---|---|
| Other Names | Alpha-2, 8-sialyltransferase 8B, 2499-, Sialyltransferase 8B, SIAT8-B, Sialyltransferase St8Sia II, ST8SiaII, Sialyltransferase X, STX, ST8SIA2, SIAT8B, STX |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6917a was selected from the N-term region of human ST8SIA2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ST8SIA2 (HGNC:10870) |
|---|---|
| Function | Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8- linked sialic acid of an N-linked glycan acceptor through alpha-2,8- linkages (Probable) (PubMed:9774483, PubMed:9054414, PubMed:10766765, PubMed:11744634). Therefore, participates in polysialic acid synthesis on various sialylated N-acetyllactosaminyl oligosaccharides (alpha- 2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid), including NCAM1, NCAM1 N-glycans, FETUB N-glycans, and to a lesser extent sialylparagloboside (SPG) and AHSG, which does not require the initial addition of an alpha 2,8-sialic acid (PubMed:7559389) (Probable). However, does not exhibit sialic acid-polymerase activity (By similarity). Catalyzes polysialic acid synthesis in the hippocampal on NCAM1 and supports neurite outgrowth (PubMed:9054414). ST8SIA2-mediated polysialylation influences on oligodendrocyte differentiation and may promote the integrity of myelin and axons (By similarity). |
| Cellular Location | Golgi apparatus membrane; Single-pass type II membrane protein. Secreted. Cell membrane Note=Also trafficks to the cell surface. |
| Tissue Location | Highly expressed in fetal brain, kidney and heart and to a much lesser extent in adult heart and thymus |
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Provided below are standard protocols that you may find useful for product applications.
Background
ST8SIA2 is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. This protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29.
References
Arai,M., et.al., Biol. Psychiatry 59 (7), 652-659 (2006)
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