|Other Names||Cerberus, Cerberus-related protein, DAN domain family member 4, CER1, DAND4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6951a was selected from the N-term region of human CER1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
CER1 is a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity.
Tang,P.L., et.al., J. Bone Miner. Res. 24 (6), 1013-1021 (2009)Swinkels,M.E., et.al., Am. J. Med. Genet. A 146A (11), 1430-1438 (2008)
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