|Other Names||WD repeat-containing protein 6, WDR6|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6954a was selected from the N-term region of human WDR6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.|
|Cellular Location||Cytoplasm. Note=Colocalizes in the cytoplasm with STK11/LKB1|
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Provided below are standard protocols that you may find useful for product applications.
WDR6 is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. This protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest.
Chiba,T., et.al., Neurobiol. Aging 30 (3), 474-482 (2009)
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