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WDR6 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NNW5 |
|---|---|
| Clone Names | 80924276 |
| Gene ID | 11180 |
|---|---|
| Other Names | WD repeat-containing protein 6, WDR6 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6954a was selected from the N-term region of human WDR6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | WDR6 |
|---|---|
| Function | Together with methyltransferase FTSJ1, methylates the 2'-O- ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs (PubMed:32558197, PubMed:33771871). Required for the correct positioning of the substrate tRNA for methylation (PubMed:32558197). Required to suppress amino acid starvation-induced autophagy (PubMed:22354037). Enhances the STK11/LKB1-induced cell growth suppression activity (PubMed:17216128). |
| Cellular Location | Cytoplasm. Note=Colocalizes in the cytoplasm with STK11/LKB1 |
| Tissue Location | Ubiquitous.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
WDR6 is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. This protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest.
References
Chiba,T., et.al., Neurobiol. Aging 30 (3), 474-482 (2009)
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