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COL25A1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BXS0 |
|---|---|
| Clone Names | 90504047 |
| Gene ID | 84570 |
|---|---|
| Other Names | Collagen alpha-1(XXV) chain, Alzheimer disease amyloid-associated protein, AMY, CLAC-P, Collagen-like Alzheimer amyloid plaque component, CLAC, COL25A1 (HGNC:18603) |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6964a was selected from the N-term region of human COL25A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | COL25A1 (HGNC:18603) |
|---|---|
| Function | Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. |
| Cellular Location | Membrane; Single-pass type II membrane protein. Note=After proteolytic cleavage, CLAC is secreted |
| Tissue Location | Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC, a soluble form of COL25A1 containing the extracellular collagen domains that associates with senile plaques in Alzheimer disease.
References
Kakuyama,H., et.al., Biochemistry 44 (47), 15602-15609 (2005)
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