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COL25A1 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9BXS0
Clone Names 90504047
Peptide ID 90504047
Additional Information
Gene ID 84570
Other Names Collagen alpha-1(XXV) chain, Alzheimer disease amyloid-associated protein, AMY, CLAC-P, Collagen-like Alzheimer amyloid plaque component, CLAC, COL25A1 (HGNC:18603)
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6964a was selected from the N-term region of human COL25A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name COL25A1 (HGNC:18603)
Function Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.
Cellular Location Membrane; Single-pass type II membrane protein. Note=After proteolytic cleavage, CLAC is secreted
Tissue Location Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease.
Research Areas
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Background

COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC, a soluble form of COL25A1 containing the extracellular collagen domains that associates with senile plaques in Alzheimer disease.

References

Kakuyama,H., et.al., Biochemistry 44 (47), 15602-15609 (2005)

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$ 80.00
Cat# BP6964a
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