|Other Names||Microtubule-associated protein RP/EB family member 3, EB1 protein family member 3, EBF3, End-binding protein 3, EB3, RP3, MAPRE3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6973c was selected from the Center region of human MAP-EB3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton Note=Associated with the microtubule network. Detected at the plus end of microtubules|
|Tissue Location||Predominantly expressed in brain and muscle.|
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Provided below are standard protocols that you may find useful for product applications.
MAP-EB3 may be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. It may play a role in cell migration.
Yeh,T.Y., et.al., J. Cell. Sci. 118 (PT 15), 3431-3443 (2005)Mimori-Kiyosue,Y.,et.al., J. Cell Biol. 168 (1), 141-153 (2005)
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