MAP-EB3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UPY8 |
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Clone Names | 90713273 |
Gene ID | 22924 |
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Other Names | Microtubule-associated protein RP/EB family member 3, EB1 protein family member 3, EBF3, End-binding protein 3, EB3, RP3, MAPRE3 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6973c was selected from the Center region of human MAP-EB3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MAPRE3 |
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Function | Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:28814570, PubMed:19255245). Promotes microtubule growth (PubMed:28814570, PubMed:19255245). May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes (PubMed:28814570, PubMed:19255245). Also acts as a regulator of minus- end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). |
Cellular Location | Cytoplasm, cytoskeleton. Note=Associated with the microtubule network. Detected at the plus end of microtubules |
Tissue Location | Predominantly expressed in brain and muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
MAP-EB3 may be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. It may play a role in cell migration.
References
Yeh,T.Y., et.al., J. Cell. Sci. 118 (PT 15), 3431-3443 (2005)Mimori-Kiyosue,Y.,et.al., J. Cell Biol. 168 (1), 141-153 (2005)
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