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FTO Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9C0B1
Clone Names 90713066
Peptide ID 90713066
Additional Information
Gene ID 79068
Other Names Alpha-ketoglutarate-dependent dioxygenase FTO, 11411-, Fat mass and obesity-associated protein, FTO, KIAA1752
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6976a was selected from the N-term region of human FTO. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FTO
Synonyms KIAA1752
Function Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Has no activity towards 1- methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.
Cellular Location Nucleus. Nucleus speckle
Tissue Location Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary.
Research Areas
Citations (0)

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The precise function of FTO remains to be determined.


Scott,L.J.,, Science 316 (5829), 1341-1345 (2007)

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$ 80.00
Cat# BP6976a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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