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GIMAP5 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96F15 |
|---|---|
| Clone Names | 90713067 |
| Gene ID | 55340 |
|---|---|
| Other Names | GTPase IMAP family member 5, Immunity-associated nucleotide 4-like 1 protein, Immunity-associated nucleotide 5 protein, IAN-5, hIAN5, Immunity-associated protein 3, GIMAP5, IAN4L1, IAN5, IMAP3 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6984c was selected from the Center region of human GIMAP5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GIMAP5 |
|---|---|
| Synonyms | IAN4L1, IAN5, IMAP3 |
| Function | Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851). Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Is a regulator of liver endothelial cell homeostasis (By similarity). |
| Cellular Location | Lysosome membrane; Single-pass type IV membrane protein. Endosome, multivesicular body membrane; Single-pass type IV membrane protein. Endosome membrane {ECO:0000250|UniProtKB:Q8K3L6}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q8K3L6} Note=The mitochondrial localization originally reported was observed with C-terminally tagged protein and was not confirmed in later publications. |
| Tissue Location | Widely expressed with high levels in lymph node and spleen (PubMed:14724691). High expression found in T lymphocytes, including CD4 and CD8-positive T-cells, and monocytes (PubMed:14724691, PubMed:29382851). Very low expression levels in B-lymphocytes (PubMed:14724691). |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
GIMAP5 is a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins.
References
Shin,J.H., et.al., Genes Immun. 8 (6), 503-512 (2007)
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$ 277.78
Cat# BP6984c
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