|Other Names||Beta-adrenergic receptor kinase 2, Beta-ARK-2, G-protein-coupled receptor kinase 3, ADRBK2, BARK2, GRK3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7005a was selected from the C-term region of human GRK3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.|
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Provided below are standard protocols that you may find useful for product applications.
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the ADRBK2 enzyme, also known as GRK3, has 85% amino acid similarity with ADRBK1, with the protein kinase catalytic domain having 95% similarity. The ADRBK2 mRNA is approximately 8 kilobases with a distribution similar to that of ADRBK1. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
Calabrese, G., et al., Genomics 23(1):286-288 (1994).Parruti, G., et al., Biochem. Biophys. Res. Commun. 190(2):475-481 (1993).Benovic, J.L., et al., J. Biol. Chem. 266(23):14939-14946 (1991).
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