|Other Names||Serine/threonine-protein kinase TAO3, Cutaneous T-cell lymphoma-associated antigen HD-CL-09, CTCL-associated antigen HD-CL-09, Dendritic cell-derived protein kinase, JNK/SAPK-inhibitory kinase, Jun kinase-inhibitory kinase, Kinase from chicken homolog A, hKFC-A, Thousand and one amino acid protein 3, TAOK3, DPK, JIK, KDS, MAP3K18|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7012c was selected from the Center region of human TAOK3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DPK, JIK, KDS, MAP3K18|
|Function||Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).|
|Cellular Location||Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also localized to the peripheral cell membrane|
|Tissue Location||Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver|
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Provided below are standard protocols that you may find useful for product applications.
TAOK3 is negatively regulated by epidermal growth factor (EGF) and inhibits the basal activity of Jun kinase. When TAOK3 is overexpressed, it may activate ERK1/ERK2 and JNK/SAPK.
Hartmann,T.B.,Br. J. Dermatol. 150 (2), 252-258 (2004)Yustein,J.T.,Oncogene 22 (40), 6129-6141 (2003)Yoneda,T.,J. Biol. Chem. 276 (17), 13935-13940 (2001)Zhang,W.,Biochem. Biophys. Res. Commun. 274 (3), 872-879 (2000)
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