|Other Names||Casein kinase II subunit beta, CK II beta, Phosvitin, Protein G5a, CSNK2B, CK2N, G5A|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7075a was selected from the N-term region of human CSNK2B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.|
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Provided below are standard protocols that you may find useful for product applications.
The beta subunit of casein kinase II is a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus.
Schwartz, E.I., et al., Mol. Cell. Biol. 24(21):9580-9591 (2004).Lee, G., et al., J. Biol. Chem. 279(8):6834-6839 (2004).Lim, A.C., et al., J. Biol. Chem. 279(6):4433-4439 (2004).Singh, D.K., et al., Virology 313(2):435-451 (2003).Kim, Y.S., et al., J. Biol. Chem. 278(31):28462-28469 (2003).
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