|Other Names||Sedoheptulokinase, SHK, Carbohydrate kinase-like protein, SHPK, CARKL|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7089a was selected from the N-term region of human CARKL. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a modulator of macrophage activation through control of glucose metabolism.|
|Tissue Location||Strongly expressed in liver, kidney and pancreas. Expressed at lower levels in placenta and heart. Very weakly expressed in lung and brain.|
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Carbohydrate kinase-like (CARKL) has contains motifs showing weak similarity to 2 domains of the FGGY family of carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this protein and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene for CARKL resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. This protein is strongly expressed in liver, kidney and pancreas, at lower levels in placenta and heart, and neglibly in lung and brain.
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