|Other Names||AarF domain-containing protein kinase 4, 2711-, ADCK4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7107a was selected from the N-term region of human ADCK4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:24270420). Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Required for podocyte migration (PubMed:24270420).|
|Cellular Location||Mitochondrion membrane; Single-pass membrane protein. Cytoplasm, cytosol. Cell membrane|
|Tissue Location||Widely expressed, including renal podocytes.|
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Provided below are standard protocols that you may find useful for product applications.
ADCK4 is member of the AarF domain containing kinase family.
Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).
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