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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   ALS2CR2 Antibody (C-term) Blocking Peptide   

ALS2CR2 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9C0K7
Clone Names 50908102
Peptide ID 50908102
Additional Information
Gene ID 55437
Other Names STE20-related kinase adapter protein beta, STRAD beta, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein, CALS-21, ILP-interacting protein, Pseudokinase ALS2CR2, STRADB, ALS2CR2, ILPIP
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7110b was selected from the C-term region of human ALS2CR2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ALS2CR2, ILPIP
Function Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).
Cellular Location Nucleus. Cytoplasm
Tissue Location Highly expressed in heart, skeletal muscle, testis, liver and colon.
Research Areas
Citations (0)

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ALS2CR2 potentiates the antiapoptotic activity of XIAP by enhancing XIAP-mediated activation of JNK1 (MAPK8) and other JNK family members, but not by modulating XIAP-mediated caspase inhibition. Expression of a catalytically inactive TAK1 (MAP3K7) mutant blocks the XIAP/ALS2CR2 activation of JNK1. In vivo coprecipitation experiments show that both ALS2CR2 and XIAP interact with TAK1 and TRAF6. It has been proposed that XIAP-mediated protection from apoptosis utilizes both a JNK1 activation pathway that involves ALS2CR2 and a caspase inhibition pathway that is independent of ALS2CR2.


Nishigaki, K., et al., J. Biol. Chem. 278(15):13520-13530 (2003).Sanna, M.G., et al., J. Biol. Chem. 277(34):30454-30462 (2002).Hadano, S., et al., Genomics 71(2):200-213 (2001).

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$ 80.00
Cat# BP7110b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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