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BCR Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P11274
Clone Names 50908105
Additional Information
Gene ID 613
Other Names Breakpoint cluster region protein, Renal carcinoma antigen NY-REN-26, BCR, BCR1, D22S11
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7113a was selected from the N-term region of human BCR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCR
Synonyms BCR1, D22S11
Function GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.
Cellular Location Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250|UniProtKB:Q6PAJ1}
Research Areas
Citations (0)

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A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac.


Burchert, A., et al., Blood 103(9):3480-3489 (2004).H, et al., Exp. Hematol. 32(5):476-482 (2004).Salesse, S., et al., Leukemia 18(4):727-733 (2004).Klein, F., et al., J. Exp. Med. 199(5):673-685 (2004).Hsu, H.C., et al., J. Lab. Clin. Med. 143(2):125-129 (2004).

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$ 80.00
Cat# BP7113a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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