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CIT Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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  • CITATIONS
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Product Information
Primary Accession O14578
Clone Names 4011406
Additional Information
Gene ID 11113
Other Names Citron Rho-interacting kinase, CRIK, Serine/threonine-protein kinase 21, CIT, CRIK, KIAA0949, STK21
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7124b was selected from the C-term region of human CIT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CIT
Synonyms CRIK, KIAA0949, STK21
Function Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Background

CIT is a putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. This protein exhibits dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. CIT plays an important role in the regulation of cytokinesis and the development of the central nervous system.

References

Liu, H., et al., J. Biol. Chem. 278(4):2541-2548 (2003).Di Cunto, F., et al., J. Biol. Chem. 273(45):29706-29711 (1998).

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$ 80.00
Cat# BP7124b
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