|Other Names||Guanylate cyclase soluble subunit alpha-3, GCS-alpha-3, GCS-alpha-1, Soluble guanylate cyclase large subunit, GUCY1A3, GUC1A3, GUCSA3, GUCY1A1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7134a was selected from the N-term region of human GUCY1A3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GUC1A3, GUCSA3, GUCY1A1|
|Tissue Location||Detected in brain cortex and lung (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.
Saino, M., et al., Oncol. Rep. 12(1):47-52 (2004).Zhou, Y., et al., Gene 245(2):319-328 (2000).Papapetropoulos, A., et al., J. Cell. Physiol. 167(2):213-221 (1996).Giuili, G., et al., Hum. Genet. 91(3):257-260 (1993).Giuili, G., et al., FEBS Lett. 304(1):83-88 (1992).
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