|Other Names||Phosphoglycerate kinase 1, Cell migration-inducing gene 10 protein, Primer recognition protein 2, PRP 2, PGK1, PGKA|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7169a was selected from the Center region of human PGK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). May play a role in sperm motility (PubMed:26677959).|
|Tissue Location||Mainly expressed in spermatogonia. Localized on the principle piece in the sperm (at protein level). Expression significantly decreased in the testis of elderly men|
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Provided below are standard protocols that you may find useful for product applications.
Also known as ATP:3-phosphoglycerate 1-phosphotransferase, this major enzyme in glycolysis catalyzes the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate, generating one molecule of ATP. Phosphoglycerate kinase not only functions in glycolysis but is secreted by tumor cells and is proposed to participate in the angiogenic process as a disulfide reductase. Mutations in PGK1 may be associated with hemolytic anemia.
Shetty, S., et al., Am. J. Respir. Cell Mol. Biol. 31(1):100-106 (2004).Daly, E.B., et al., Biochim. Biophys. Acta 1691(1):17-22 (2004).Daly, E.B., et al., Int. J. Biol. Markers 19(2):170-172 (2004).Saito, Y., et al., Biochem. Biophys. Res. Commun. 314(2):396-402 (2004).Krishnan, P., et al., J. Biol. Chem. 278(38):36726-36732 (2003).
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