|Other Names||Selenide, water dikinase 2, Selenium donor protein 2, Selenophosphate synthase 2, SEPHS2, SPS2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7188a was selected from the N-term region of human SEPSH2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Synthesizes selenophosphate from selenide and ATP.|
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Provided below are standard protocols that you may find useful for product applications.
This protein encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. This protein itself contains a selenocysteine residue in its predicted active site. The 3' UTR of the gene has a stem-loop secondary structure called a selenocysteine insertion sequence (SECIS) element, which allows UGA to direct the incorporation of selenocysteine rather than signal a translational stop.
Tamura, T., et al., Proc. Natl. Acad. Sci. U.S.A. 101(46):16162-16167 (2004).Lescure, A., et al., J. Biol. Chem. 274(53):38147-38154 (1999).Guimaraes, M.J., et al., Proc. Natl. Acad. Sci. U.S.A. 93(26):15086-15091 (1996).Guimaraes, M.J., et al., Development 121(10):3335-3346 (1995).
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