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SPHK1 Antibody (C-term R414) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9NYA1
Other Accession Q8N632
Peptide ID 26868
Additional Information
Gene ID 8877
Other Names Sphingosine kinase 1, SK 1, SPK 1, SPHK1, SPHK, SPK
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPHK1
Synonyms SPHK, SPK
Function Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.
Cellular Location Cytoplasm. Nucleus. Cell membrane. Note=Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner
Tissue Location Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle
Research Areas
Citations (0)

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SPHK1 is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1 (MIM 601974). Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (e.g., MIM 173430) and serum.


Hengst, J.A., et al. Arch. Biochem. Biophys. 494(1):23-31(2010)Jarman, K.E., et al. J. Biol. Chem. 285(1):483-492(2010)Gamble, J.R., et al. Am. J. Pathol. 175(5):2217-2225(2009)

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$ 80.00
Cat# BP7237b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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