|Other Names||Calcium/calmodulin-dependent protein kinase type 1G, CaM kinase I gamma, CaM kinase IG, CaM-KI gamma, CaMKI gamma, CaMKIG, CaMK-like CREB kinase III, CLICK III, CAMK1G, CLICK3, VWS1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7253c was selected from the Center region of human CAMK1G. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity).|
|Cellular Location||Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein Cell membrane; Peripheral membrane protein|
|Tissue Location||Mainly expressed in brain with small amounts in skeletal muscles, kidney, spleen and liver. Strongly expressed in forebrain neocortex, striatum and limbic system|
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Provided below are standard protocols that you may find useful for product applications.
Ca2+/calmodulin-dependent protein kinase I (CaMKI) constitutes a family of closely related isoforms (alpha, beta and gamma). CLICK-III/CaMKIgamma is a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase. AMKIgamma is abundant in neurons, particularly in the amygdala and ventromedial hypothalamus. Like the other CaMKI isoforms, full activation of CLICK-III/CaMKIgamma requires both Ca(2+)/CaM and phosphorylation by CaMKK.
Takemoto-Kimura, S., et al., J. Biol. Chem. 278(20):18597-18605 (2003).Schutte, B.C., et al., Genome Res. 10(1):81-94 (2000).
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