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Cdc25B Antibody (N-term) (A166) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P30305
Clone Names 5021455
Peptide ID 5021455
Additional Information
Gene ID 994
Other Names M-phase inducer phosphatase 2, Dual specificity phosphatase Cdc25B, CDC25B, CDC25HU2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7256d was selected from the N-term region of human Cdc25B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDC25B
Synonyms CDC25HU2
Function Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole
Research Areas
Citations (0)

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CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined.


Uchida, S., et al., Biochem. Biophys. Res. Commun. 316(1):226-232 (2004).Ito, Y., et al., Int. J. Mol. Med. 13(3):431-435 (2004).Wu, W., et al., Cancer Res. 63(19):6195-6199 (2003).Mils, V., et al., Exp. Cell Res. 285(1):99-106 (2003).Theis-Febvre, N., et al., Oncogene 22(2):220-232 (2003).

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$ 80.00
Cat# BP7256d
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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