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NAE1 (APPBP1) Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q13564
Other Accession NP_003896
Clone Names 80102130
Peptide ID 80102130
Additional Information
Gene ID 8883
Other Names NEDD8-activating enzyme E1 regulatory subunit, Amyloid beta precursor protein-binding protein 1, 59 kDa, APP-BP1, Amyloid protein-binding protein 1, Proto-oncogene protein 1, NAE1, APPBP1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7273e was selected from the C-term region of human APPBP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NAE1
Synonyms APPBP1
Function Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
Cellular Location Cell membrane. Note=Colocalizes with APP in lipid rafts
Tissue Location Ubiquitous in fetal tissues. Expressed throughout the adult brain.
Research Areas
Citations (0)

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APPBP1 binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, this protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. APPBP1 is required for cell cycle progression through the S/M checkpoint.


Chen,Y., J. Cell Biol. 163 (1), 27-33 (2003)Chen,Y., J. Neurochem. 85 (3), 801-809 (2003)Walden,H., Nature 422 (6929), 330-334 (2003)Chow,N., J. Biol. Chem. 271 (19), 11339-11346 (1996)

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$ 80.00
Cat# BP7273e
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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