|Other Names||Homeobox protein BarH-like 1, BARX1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7276c was selected from the Center region of human BarX1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity (By similarity). Binds to a regulatory module of the NCAM promoter.|
|Tissue Location||Widely expressed. Expressed at higher levels in testis and heart. Detected in craniofacial tissue and adult iris, but not in lymphocytes, fibroblasts, choroid retina, retinal pigment epithelium, kidney, or fetal liver|
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BarX1 is a member of the Bar subclass of homeobox transcription factors. Studies of the mouse and chick homolog suggest this protein may play a role in developing teeth and craniofacial mesenchyme of neural crest origin. The protein may also be associated with differentiation of stomach epithelia.
Lowry,R.B., Am. J. Med. Genet. A 143 (11), 1227-1230 (2007)Gould,D.B., Genomics 68 (3), 336-342 (2000)
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