|Other Names||Insulin, Insulin B chain, Insulin A chain, INS|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7277b was selected from the C-term region of human INS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.|
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Provided below are standard protocols that you may find useful for product applications.
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake.
Nordquist,L., Diabetes Metab. Res. Rev. 24 (2), 165-168 (2008)Nordquist,L., (er) Am. J. Physiol. Regul. Integr. Comp. Physiol. (2007) In pressNaya,T., Angiology 58 (6), 677-684 (2007)
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