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LINGO1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96FE5
Clone Names 5111871
Additional Information
Gene ID 84894
Other Names Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat and immunoglobulin domain-containing protein 1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat neuronal protein 6A, LINGO1, LERN1, LRRN6A
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7284b was selected from the C-term region of human LINGO1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms LERN1, LRRN6A
Function Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients
Research Areas
Citations (0)

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LINGO1 is a functional component of the Nogo receptor signaling complex(RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. It is also an important negative regulator of oligodentrocyte differentiation and axonal myelination.


Inoue,H., Proc. Natl. Acad. Sci. U.S.A. 104 (36), 14430-14435 (2007)Satoh,J., Neuropathol. Appl. Neurobiol. 33 (1), 99-107 (2007)Mosyak,L., J. Biol. Chem. 281 (47), 36378-36390 (2006)Mi,S., Nat. Neurosci. 7 (3), 221-228 (2004)

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$ 80.00
Cat# BP7284b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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