BTC Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P35070 |
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Other Accession | Q96F48 |
Clone Names | 71211119 |
Gene ID | 685 |
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Other Names | Probetacellulin, Betacellulin, BTC, BTC |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7290c was selected from the Center region of human BTC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | BTC |
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Function | Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. |
Cellular Location | [Betacellulin]: Secreted, extracellular space. |
Tissue Location | Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine |
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Provided below are standard protocols that you may find useful for product applications.
Background
Betacellulin (BTC) is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. It is a ligand for the EGF receptor.
References
Sasada R.,Biochem. Biophys. Res. Commun. 190:1173-1179(1993).Seno,M., Growth Factors 13 (3-4), 181-191 (1996)Pathak,B.G., Genomics 28 (1), 116-118 (1995)
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