|Other Names||Probetacellulin, Betacellulin, BTC, BTC|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7290c was selected from the Center region of human BTC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.|
|Cellular Location||Betacellulin: Secreted, extracellular space.|
|Tissue Location||Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine|
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Provided below are standard protocols that you may find useful for product applications.
Betacellulin (BTC) is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. It is a ligand for the EGF receptor.
Sasada R.,Biochem. Biophys. Res. Commun. 190:1173-1179(1993).Seno,M., Growth Factors 13 (3-4), 181-191 (1996)Pathak,B.G., Genomics 28 (1), 116-118 (1995)
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