|Other Names||Probetacellulin, Betacellulin, BTC, BTC|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7290c was selected from the Center region of human BTC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.|
|Cellular Location||Betacellulin: Secreted, extracellular space.|
|Tissue Location||Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Betacellulin (BTC) is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. It is a ligand for the EGF receptor.
Sasada R.,Biochem. Biophys. Res. Commun. 190:1173-1179(1993).Seno,M., Growth Factors 13 (3-4), 181-191 (1996)Pathak,B.G., Genomics 28 (1), 116-118 (1995)
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