|Other Names||Carbonic anhydrase-related protein 11, CA-RP XI, CA-XI, CARP XI, Carbonic anhydrase-related protein 2, CA-RP II, CARP-2, CA11, CARP2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7304b was selected from the C-term region of human CA11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Does not have a catalytic activity.|
|Tissue Location||Expressed abundantly in the brain with moderate expression also present in spinal cord and thyroid|
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Provided below are standard protocols that you may find useful for product applications.
CA11 belongs a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. CA11 is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. This protein shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. The protein is most abundantly expressed in brain, and may play a general role in the central nervous system.
Bellingham,J. Biochem. Biophys. Res. Commun. 253 (2), 364-367 (1998)Lovejoy,D.A., Hewett-Emmett,D. Genomics 54 (3), 484-493 (1998)
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