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PRC1 Antibody (Center H439) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O43663
Clone Names 80917160
Peptide ID 80917160
Additional Information
Gene ID 9055
Other Names Protein regulator of cytokinesis 1, PRC1 {ECO:0000312|EMBL:AAC026881}
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7317c was selected from the Center region of human PRC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRC1 {ECO:0000312|EMBL:AAC02688.1}
Function Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle.
Cellular Location Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Predominantly localized to the nucleus of interphase cells. During mitosis becomes associated with the mitotic spindle poles and localizes with the cell midbody during cytokinesis
Research Areas
Citations (0)

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PRC1 is involved in cytokinesis. The protein is at high level during S and G2/M and drop dramatically after cell exit mitosis and enter G1. It is located in the nucleus during interphase, and becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs).


Murphy,L.A., Wilkerson,D.C. Exp. Cell Res. 314 (11-12), 2224-2230 (2008)Shimo,A., Nishidate,T. Cancer Sci. 98 (2), 174-181 (2007)Zhu,C., Lau,E. Proc. Natl. Acad. Sci. U.S.A. 103 (16), 6196-6201 (2006)

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$ 80.00
Cat# BP7317c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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