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BTBD1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H0C5 |
|---|---|
| Clone Names | 80902074 |
| Gene ID | 53339 |
|---|---|
| Other Names | BTB/POZ domain-containing protein 1, Hepatitis C virus NS5A-transactivated protein 8, HCV NS5A-transactivated protein 8, BTBD1, C15orf1, NS5ATP8 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7323c was selected from the Center region of human BTBD1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | BTBD1 |
|---|---|
| Synonyms | C15orf1, NS5ATP8 |
| Function | Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity). |
| Cellular Location | Cytoplasm. Note=Localizes to punctate or elongated cytoplasmic bodies. |
| Tissue Location | Ubiquitous; highest levels in testes, heart and skeletal muscle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
BTBD1 binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies.
References
Pisani,D.F., Cabane,C. Cell Death Differ. 11 (11), 1157-1165 (2004)Xu,L., Yang,L. Exp. Cell Res. 288 (1), 84-93 (2003)Xu,L., Yang,L. BMC Genomics 3 (1), 1 (2002)
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