|Other Names||BTB/POZ domain-containing protein 1, Hepatitis C virus NS5A-transactivated protein 8, HCV NS5A-transactivated protein 8, BTBD1, C15orf1, NS5ATP8|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7323c was selected from the Center region of human BTBD1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.|
|Cellular Location||Cytoplasm, P-body. Note=Cytoplasmic bodies|
|Tissue Location||Ubiquitous; higher levels in heart and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
BTBD1 binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies.
Pisani,D.F., Cabane,C. Cell Death Differ. 11 (11), 1157-1165 (2004)Xu,L., Yang,L. Exp. Cell Res. 288 (1), 84-93 (2003)Xu,L., Yang,L. BMC Genomics 3 (1), 1 (2002)
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