|Other Names||Krueppel-like factor 5, Basic transcription element-binding protein 2, BTE-binding protein 2, Colon krueppel-like factor, GC-box-binding protein 2, Intestinal-enriched krueppel-like factor, Transcription factor BTEB2, KLF5, BTEB2, CKLF, IKLF|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7342c was selected from the Center region of human KLF5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BTEB2, CKLF, IKLF|
|Function||Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.|
|Tissue Location||Expressed only in testis and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
KLF5 is a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, the protein is thought to be a transcription factor.
Guo,P., Dong,X.Y. J. Biol. Chem. 284 (10), 6071-6078 (2009)Lee,M.Y., Moon,J.S. Biochem. J. 417 (1), 313-322 (2009)Du,J.X., Bialkowska,A.B. J. Biol. Chem. 283 (46), 31991-32002 (2008)Miyamoto,S., Suzuki,T. Mol. Cell. Biol. 23 (23), 8528-8541 (2003)Shi,H., Zhang,Z. Nucleic Acids Res. 27 (24), 4807-4815 (1999)
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