|Other Names||Peptidyl-prolyl cis-trans isomerase G, PPIase G, Peptidyl-prolyl isomerase G, CASP10, Clk-associating RS-cyclophilin, CARS-Cyp, CARS-cyclophilin, SR-cyclophilin, SR-cyp, SRcyp, Cyclophilin G, Rotamase G, PPIG|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7353c was selected from the Center region of human PPIG. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.|
|Cellular Location||Nucleus matrix. Nucleus speckle. Note=Colocalizes with RNA splicing factors at nuclear speckles|
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Provided below are standard protocols that you may find useful for product applications.
PPIases accelerate the folding of proteins. The Protein catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. It may be implicated in the folding, transport, and assembly of proteins and May play an important role in the regulation of pre-mRNA splicing.
Lin,C.L., Biochem. Biophys. Res. Commun. 321 (3), 638-647 (2004)Jin,J., Curr. Biol. 14 (16), 1436-1450 (2004)
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