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BCOR Antibody (Center S1122) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q6W2J9
Clone Names 80722024
Peptide ID 80722024
Additional Information
Gene ID 54880
Other Names BCL-6 corepressor, BCoR, BCOR, KIAA1575
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7359c was selected from the Center region of human BCOR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA1575
Function Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
Cellular Location Nucleus.
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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BCOR was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs.


Ghetu,A.F., Mol. Cell 29 (3), 384-391 (2008)Hilton,E.N., Hum. Mol. Genet. 16 (14), 1773-1782 (2007)

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$ 80.00
Cat# BP7359c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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